Interleukin-6 Limits Host Susceptibility to Urinary Tract Infection by Promoting Urothelial Expulsion of Intracellular Bacteria
IL-6 facilitates UPEC expulsion, limiting intracellular UPEC early in infection and thus the initial formation of IBCs. Since IBC formation is a bottleneck in UPEC survival during UTI, these findings identify a mechanism whereby IL-6 reduces early UPEC urothelial infectivity.
Authors
- Hanna H. Cortado
- Brian Becknell (ORCID: https://orcid.org/0000-0002-2750-4415)
- Sudipti Gupta (ORCID: https://orcid.org/0000-0001-7574-5064)
- Shradha Rajak
- John David Spencer
- Christina Barbara Ching
Institutions
- Nationwide Children's Hospital (US)
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1159/000550787
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases