Pedunculoside ameliorates metabolic dysfunction-associated steatotic liver disease by targeting HNRNPA1 and modulating PPARα signaling pathway to enhance Mitochondrial Fatty Acid β-Oxidation
Our study uncovers a novel therapeutic axis in MASLD, in which PE enhances the stability of PPARα mRNA by directly binding to HNRNPA1, and consequently upregulates fatty acid β-oxidation. These findings not only position PE as a promising therapeutic candidate for MASLD but also identify the HNRNPA1-PPARα regulatory pathway as a potential mechanistic target for treating metabolic liver diseases.
Authors
- Jingyun Chi
- Huazhou Fu
- Xizhen Zhou
- Tao Zhang (ORCID: https://orcid.org/0000-0003-2673-9914)
- Tianhao Wang (ORCID: https://orcid.org/0000-0002-1210-3192)
- Yang Zhou (ORCID: https://orcid.org/0000-0002-5144-7756)
- Kun Zhao (ORCID: https://orcid.org/0000-0001-9871-4957)
- Xining Xu
- Dandan Hong
- Rongrong Zhu
Institutions
- Suzhou University of Science and Technology (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Shanghai Sixth People's Hospital (CN)
- Suzhou Vocational Health College (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1016/j.phymed.2026.157910
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00