Synergistic Effects of Honokiol on Camptothecin-triggered Apoptosis of Drug-resistant Glioblastoma Cells <i>via</i> CDK1-mediated G <sub>2</sub> /M Arrest and Intrinsic ROS-Mitochondrion-dependent Pathway
HNK synergistically enhances CPT-induced apoptosis in TMZ-resistant glioblastoma cells through CDK1-mediated G<sub>2</sub>/M arrest and ROS-dependent mitochondrial activation of caspases-9, -3, and -6. Co-administration of HNK may enable effective CPT-based therapy at reduced doses, potentially minimizing CPT-related toxicity and offering a promising strategy for treating drug-resistant GBM.
Authors
- Chih-Pin Yang
- Jui‐Tai Chen (ORCID: https://orcid.org/0000-0002-4018-7303)
- Edwin Chen (ORCID: https://orcid.org/0000-0003-0742-9734)
- Ruei Ming Chen
- Shing-Hwa Liu
Institutions
- University of British Columbia (CA)
- National Taiwan University (TW)
- Taipei Medical University Hospital (TW)
- Chi Mei Medical Center (TW)
- Wan Fang Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Anticancer Research
- Published
- 2026-01-30
- DOI
- https://doi.org/10.21873/anticanres.17975
- Primary Topic
- Magnolia and Illicium research
- Type
- article
- Field-Weighted Citation Impact
- 0.00