Alteration of Flavin Homeostasis in Uterine Cancer
A coordinated mechanism where uterine cancer cells adaptively up-regulate RFVTs, FADS, and LSD1 to meet their metabolic demands was revealed. These results provide insights into the metabolic vulnerabilities of uterine cancer and propose Rf metabolism and flavin-dependent processes as potential therapeutic targets.
Authors
- Mariafrancesca Scalise (ORCID: https://orcid.org/0000-0003-3860-6844)
- Maria Tolomeo (ORCID: https://orcid.org/0000-0002-7998-5281)
- Maria Barile (ORCID: https://orcid.org/0000-0001-5025-551X)
- Angela Sposato
- Alessia Nisco
- Didier Paleni
Institutions
- Université Paris Lumières (FR)
- Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IT)
- University of Calabria (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Anticancer Research
- Published
- 2026-01-30
- DOI
- https://doi.org/10.21873/anticanres.17978
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 24.82