New pyrimidine derivatives as potential agents against hepatocellular carcinoma: design, synthesis, and in vitro and in vivo biological evaluations
Based on these results, this pyrimidine derivative could be an interesting compound for the design of new agents against HCC.
Authors
- Santibáñez Jf
- Thalía Delgado (ORCID: https://orcid.org/0000-0001-8189-0022)
- Javier Echeverría (ORCID: https://orcid.org/0000-0002-1688-968X)
- Ignacio Montorfano
- Ramón Pérez-Castro (ORCID: https://orcid.org/0000-0003-3943-6269)
- Iván Brito (ORCID: https://orcid.org/0000-0001-6077-2457)
- Ricardo O. Valdés-Valdés
- A. L. Cabrera
- Jacqueline Romero
- Cristian O. Salas
- César Echeverría
- Jeanluc Bertrand
- María Paola Vieytes
Institutions
- Universidad de Santiago de Chile (CL)
- Universidad de Antofagasta (CL)
- Pontificia Universidad Católica de Chile (CL)
- University of Atacama (CL)
- Catholic University of the Maule (CL)
- University of Belgrade (RS)
- University of the Americas (CL)
- Universidad de Las Américas (EC)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fphar.2026.1745214
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Pontificia Universidad Católica de Chile