Methyltransferase-like 14 suppresses the retinal neovascularization by reducing HIF-1α in proliferative retinopathy
This study suggests that METTL14-mediated m<sup>6</sup>A modification is a pivotal step in regulating the pathogenesis of retinal neovascularization. Therefore, METTL14 might be introduced as a promising therapeutic strategy for the management of PR. However, our findings are limited by the types of clinical samples, and further validation in larger clinical cohorts is required.
Authors
- Qiang Hu (ORCID: https://orcid.org/0000-0003-0954-3450)
- Zhangxin Huang
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Wei Sang
- Jitian Guan
- Xiaoning Wang
- Dawei Sun
- Bo Jiang
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s40001-026-03883-2
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00