Global pharmacovigilance analysis of antimicrobials used in periodontal therapy: safety profiles of minocycline, doxycycline, and chlorhexidine
Adjunctive antimicrobial agents used in periodontal therapy demonstrate heterogeneous real-world safety signal profiles. Disproportionality patterns indicate that local administration does not preclude systemic biological relevance, underscoring the need for agent-specific, guideline-concordant risk-benefit assessment in clinical decision-making.
Authors
- Deborah Kreher (ORCID: https://orcid.org/0009-0005-3237-6330)
- Linxin Jiang (ORCID: https://orcid.org/0000-0003-3806-8337)
- Gerhard Schmalz (ORCID: https://orcid.org/0000-0002-6602-377X)
- Daniel Ralph Reissmann (ORCID: https://orcid.org/0000-0003-3588-5665)
- Shaohong Huang (ORCID: https://orcid.org/0000-0002-9169-484X)
- Wanchen Ning
- Simin Li
- Xiangyu Huang
- Hongxing Chu
Institutions
- Leipzig University of Applied Sciences (DE)
- Guangdong Province Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- Southern Medical University (CN)
- Leipzig University (DE)
Publication Details
- Journal
- Head & Face Medicine
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s13005-026-00590-5
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00