Activated Loofah Sponge Carbon/Poly (3,4‐Ethylenedioxythiophene)‐Gold Composite Electrochemical Sensor for the Determination of Luteolin

ABSTRACT Testing luteolin is essential to promote its appropriate clinical use, regulate the quality of pharmaceuticals and safeguard public health. In this work, the activated loofah sponge carbon/poly(3,4‐ethylenedioxythiophene)‐gold nanocomposites (LSAC/PEDOT‐Au) were successfully prepared through an efficient and straightforward method. The surface morphology and structural characteristics of the synthesized nanocomposites were systematically characterized. A glassy carbon electrode (GCE) modified with LSAC/PEDOT‐Au nanocomposites was fabricated as a novel luteolin sensor. At the optimal experimental conditions, the LSAC/PEDOT‐Au/GCE exhibited a high sensitivity of 3.3 × 10 −9 mol dm −3 and a wide linear range of 0.05–2 and 2–40 µmol dm −3 toward luteolin oxidation, demonstrating satisfactory selectivity and stability. In addition, the developed LSAC/PEDOT‐Au/GCE was further evaluated for its ability to detect luteolin in honeysuckle samples, yielding highly satisfactory results.