Predictors of Loco-Regional Recurrence after Pulmonary Non-Anatomical Metastasectomy: A Multicentre Retrospective Analysis

Objectives: This study aimed at identifying predictors of loco-regional recurrence in patients who underwent non-anatomical (wedge) resection(s) of lung metastases at 15 European centres. Methods: Multicentre retrospective analysis of patients ≥18 years who underwent curative-intent wedge resection(s) of lung metastases (01/2010-12/2018). Exclusion criteria were: previous metastasectomy, non-curative intent, incomplete (R1/R2) resection, and lack of data concerning recurrence. Loco-regional recurrence was defined as any recurrence occurring in the lungs, hilar-mediastinal lymph nodes, and/or pleurae. Unlabelled: Subset analyses were conducted on patients with a solitary metastasis. Conclusions: Loco-regional recurrence after pulmonary metastasectomy seems to be correlated with primary tumour histology and number of metastases. Further studies are needed to clarify the role of size-adjusted margin parameters in preventing recurrence.