Epigenome-wide association study of leukocyte telomere length and their effects on smoking-induced lung tumorigenesis: insights from the Dongfeng-Tongji cohort study
Both TL attrition and the three candidate CpGs showed significant mediation effects on lung cancer risk induced by smoking. These findings provide novel insight into the epigenetic control of telomere homeostasis mechanisms and clues for methylation alteration and TL in smoking-induced lung tumorigenesis.
Authors
- Shiru Hong
- Shengli Chen (ORCID: https://orcid.org/0009-0006-4915-0853)
- Yingqian You
- Chenming Wang (ORCID: https://orcid.org/0009-0007-2895-1421)
- Yuxi Wang (ORCID: https://orcid.org/0009-0004-3022-8716)
- Yong Zhang (ORCID: https://orcid.org/0000-0003-2179-3698)
- Shujun Cheng (ORCID: https://orcid.org/0000-0001-6376-5383)
- Ming Fu (ORCID: https://orcid.org/0000-0001-9256-2331)
- Yang Xiao
- Xin Guan
- Yansen Bai
- Yuhan Zhou
- Ye Fu
- Yi Jiang
- Hui Zhao
- Huan Guo
Institutions
- Huazhong University of Science and Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s13148-026-02053-9
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00