Effect of long-term adherence on faecal immunochemical test positivity rate, positive predictive value and detection rate in organised population-based colorectal cancer screening

After an initial round with the highest FIT-positivity and detection rates, screening outcomes stabilise at lower levels reflecting neoplasia removal and subsequent selection of a lower-risk population. Because detection rates remain clinically relevant even in an adherent cohort, early screening cessation after a sequence of normal biennial FITs is not justified.

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Publication Details

Journal
Gut
Published
2026-01-30
DOI
https://doi.org/10.1136/gutjnl-2025-336994
Primary Topic
Colorectal Cancer Screening and Detection
Type
article
Field-Weighted Citation Impact
0.00
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article

Effect of long-term adherence on faecal immunochemical test positivity rate, positive predictive value and detection rate in organised population-based colorectal cancer screening

Josep Alfons Espinàs Piñol, A. Castells, Judit Solà, Uri Ladabaum et al.
Gut
Colorectal Cancer Screening and Detection
article

Effect of long-term adherence on faecal immunochemical test positivity rate, positive predictive value and detection rate in organised population-based colorectal cancer screening

Josep Alfons Espinàs Piñol, A. Castells, Judit Solà, Uri Ladabaum, Rebeca Font Marimon, Maria Pellisé, Xavier Castells Olivera
article en

Abstract

After an initial round with the highest FIT-positivity and detection rates, screening outcomes stabilise at lower levels reflecting neoplasia removal and subsequent selection of a lower-risk population. Because detection rates remain clinically relevant even in an adherent cohort, early screening cessation after a sequence of normal biennial FITs is not justified.

Gut
Universitat Pompeu Fabra (ES), Institut d'Investigació Biomédica de Bellvitge (ES), Red de Investigación en Actividades Preventivas y Promoción de la Salud (ES), Institut Català d'Oncologia (ES), Hospital Clínic de Barcelona (ES), Hospital Del Mar (ES), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES), Stanford Medicine (US), Stanford University (US)
Openalex Percentile: Top 72%
Colorectal Cancer Screening and Detection
DOISourceOpenAlex
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Effect of long-term adherence on faecal immunochemical test positivity rate, positive predictive value and detection rate in organised population-based colorectal cancer screening — Josep Alfons Espinàs Piñol, A. Castells, et al. · Gut (2026) | TGRS Research Map | TGRS