Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque
Broadly neutralizing antibodies targeting HIV-1 envelope surface protein develop via a common maturation pathway across primate phylogeny.
Authors
- James P. Ludwig
- S. Gobeil (ORCID: https://orcid.org/0000-0002-0057-2477)
- Lorie Marchitto (ORCID: https://orcid.org/0000-0002-4367-0229)
- Tyler Evangelous (ORCID: https://orcid.org/0000-0001-9858-2114)
- Juliette M. Rando (ORCID: https://orcid.org/0000-0002-1742-9255)
- Ashwin N. Skelly (ORCID: https://orcid.org/0000-0002-1565-3376)
- Andrew Jesse Connell (ORCID: https://orcid.org/0000-0002-9393-3074)
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Jared Lindenberger (ORCID: https://orcid.org/0000-0003-2044-6715)
- Chengyan Zhao
- Wilton B. Williams (ORCID: https://orcid.org/0000-0002-2970-7259)
- Sravani Venkatayogi (ORCID: https://orcid.org/0000-0001-8976-6827)
- Shuyi Wang
- RW Sanders
- Wenge Ding (ORCID: https://orcid.org/0000-0002-7574-4202)
- Marit van Gils
- Kevin Wiehe
- Barton F. Haynes
- Katayoun Mansouri
- Mitchell Martin
- Seth Rohr
- Matthew Clark
- Kshitij Wagh
- Younghoon Park (ORCID: https://orcid.org/0009-0003-5069-504X)
- Nicole A Doria-Rose
- Michael Hogarty
- Kevin O'Neil Saunders
- John Mascola
- Beatrice H Hahn
- George M Shaw
- Robert J. Edwards
- Madison Berry
- John Carey
- Bette Korber
- Yue Chen
- Bhavna Hora
- Priyamvada Acharya
Institutions
- National Institutes of Health (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Los Alamos National Laboratory (US)
- Duke University (US)
- East Carolina University (US)
- Cornell University (US)
- Yale University (US)
- Clinical Research Institute (US)
- Fred Hutch Cancer Center (US)
- Netherlands Center for Occupational Diseases (NL)
- New Mexico Consortium (US)
- Amsterdam University Medical Centers (NL)
- Laboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique (FR)
- Université Laval (CA)
- Weill Cornell Medicine (US)
- University of Pennsylvania (US)
- University of Amsterdam (NL)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-30
- DOI
- https://doi.org/10.64898/2026.01.29.702664
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00