Role of comorbidities and medication on immunotherapy efficacy in cSCC: A DeCOG multicentre analysis
Our analyses suggest that immunosuppressive disease is an independent predictor of shortened OS, underscoring the critical role of host immune competence. We further report a novel, independently significant association between anticoagulant use and prolonged PFS. Other associations should be regarded as exploratory. These findings highlight host-related factors as potential modulators of ICI efficacy and merit prospective validation.
Authors
- Daniel J. Smit (ORCID: https://orcid.org/0000-0002-3190-9511)
- Alexandra Geusau (ORCID: https://orcid.org/0000-0003-0347-065X)
- Christoffer Gebhardt (ORCID: https://orcid.org/0000-0001-7090-9584)
- S. Grabbe
- Michael Weichenthal (ORCID: https://orcid.org/0000-0002-9060-4961)
- Julian Kött (ORCID: https://orcid.org/0000-0003-2073-3909)
- Isabel Heidrich (ORCID: https://orcid.org/0000-0001-6894-1913)
- Glenn Geidel (ORCID: https://orcid.org/0009-0008-3999-5902)
- M Heppt
- Simon Jc
- E. Dippel
- Alessandra Rünger (ORCID: https://orcid.org/0000-0002-4465-5282)
- C. Berking
- Stefan W. Schneider (ORCID: https://orcid.org/0000-0002-4679-7137)
- Ulrike Leiter (ORCID: https://orcid.org/0000-0002-8019-1577)
- Tim Zell (ORCID: https://orcid.org/0009-0004-8096-7402)
- L. Susok
- Laura Adam
- Sabrina Bänsch
- Nathan Fekade
- Selma Ugurel
- Sebastian Haferkamp
- Jessica C. Hassel
- Bastian Schilling
- Peter Mohr
- Jochen Utikal
- Imke von Wasielewski
Institutions
- Goethe University Frankfurt (DE)
- Universität Hamburg (DE)
- University of Mannheim (DE)
- German Cancer Research Center (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Hospital Regensburg (DE)
- Medizinische Hochschule Hannover (DE)
- Universitätsklinikum Erlangen (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- National Center for Tumor Diseases (DE)
- University Hospital Schleswig-Holstein (DE)
- University Hospital Leipzig (DE)
- University Cancer Center Hamburg (DE)
- Klinikum Dortmund (DE)
- Klinikum Ludwigshafen (DE)
- Klinikum Bielefeld (DE)
- University Hospital Frankfurt (DE)
- Elbe Kliniken Stade-Buxtehude (DE)
- University Medical Centre Mannheim (DE)
- Johannes Wesling Klinikum Minden (DE)
- University of Regensburg (DE)
- Medical University of Vienna (AT)
- University of Tübingen (DE)
- Leipzig University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1111/jdv.70307
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Bristol-Myers Squibb
- Sanofi
- Regeneron Pharmaceuticals
- Deutsche Forschungsgemeinschaft
- Sun Pharma
- Universitätsklinikum Hamburg-Eppendorf