Crystalloids as an alternative to whole blood in pREBOA resuscitation for hemorrhagic shock

Crystalloid resuscitation during pREBOA maintained mean arterial pressure and cardiac output comparable to whole blood, with high-volume crystalloids offering superior hemodynamic support compared to low-volume resuscitation. High-volume crystalloids improved stroke volume. Metabolic stability was preserved across groups, with no severe derangements observed. These findings highlight crystalloids as a potential alternative in resource-limited settings, although reduced renal perfusion warrants further investigation to optimize outcomes and ensure broader clinical applicability.