Causes of Fever in a Cohort of Nepali Children and the Potential Impact of Molecular Testing During a Dengue Fever Outbreak
This prospective cohort study is the most comprehensive effort to date to describe the causes of pediatric fever in the Kathmandu Valley, Nepal. The United States Centers for Disease Control and Prevention recommends dengue PCR or NS1 antigen testing during the first 7 days of dengue fever. Our data indicate that PCR positivity declines after 3 days of symptoms, resulting in missed cases when relying solely on PCR.
Authors
- Sanjeev Man Bijukchhe (ORCID: https://orcid.org/0000-0002-6436-6859)
- Elizabeth O’Mahony
- Ruby Basi
- Shriya Bista
- Anushiya Kattel
- Colin G. Fink (ORCID: https://orcid.org/0000-0002-8008-5870)
- Kushal Gautam
- Bhishma Pokhrel (ORCID: https://orcid.org/0000-0003-0972-6716)
- Michael James Carter
- Sarah Kelly (ORCID: https://orcid.org/0000-0002-1114-2456)
- Shreekrishna Maharjan (ORCID: https://orcid.org/0000-0002-8262-628X)
- Catherine H. Davis (ORCID: https://orcid.org/0000-0002-0976-8054)
- Roshan Kumar Jha (ORCID: https://orcid.org/0000-0001-6796-7193)
- Ganesh Shah (ORCID: https://orcid.org/0000-0002-3704-6745)
- Saugat Bhandari
- Ira Shrestha
- Puja Amatya
- Meeru Gurung
- Andrew Taylor
- Aubrey J. Cunnington
- Ram Khadka
- Andrew J. Pollard
Institutions
- Patan Academy of Health Sciences (NP)
- Centre for Human Genetics (GB)
- University of Oxford (GB)
- Coventry (United Kingdom) (GB)
- Oxford BioMedica (United Kingdom) (GB)
- Royal College of Paediatrics and Child Health (GB)
- University of Warwick Science Park (GB)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1097/inf.0000000000005167
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00