Dimensional Priming Reprograms Adipose-Derived Stromal Cells to Promote Pancreatic Cancer Progression
Dimensional priming fundamentally reprograms ADSC phenotype and alters their stromal-immune interactions, generating a tumor-permissive state that accelerates PDAC progression. These findings identify mechanical cues as critical regulators of stromal plasticity and highlight dimensional priming as a potentially targetable axis within the PDAC microenvironment.
Authors
- Thomas D. Schmittgen (ORCID: https://orcid.org/0000-0002-2812-8546)
- Ba X. Hoang (ORCID: https://orcid.org/0000-0003-2712-9747)
- Bo Han (ORCID: https://orcid.org/0000-0002-6509-0313)
- Z. P. Yao
- Shuqing Zhao
- Jamel Ali
Institutions
- University of Southern California (US)
- Florida A&M University - Florida State University College of Engineering (US)
- University of Florida (US)
Publication Details
- Journal
- Cancers
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3390/cancers18030460
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00