Baseline Nonperfusion and Deep Capillary Plexus Ischemia Predict Two-Year Retinal Nonperfusion Progression in Diabetic Retinopathy
In this cohort, baseline UWF-FA nonperfusion was the strongest predictor of retinal nonperfusion progression, whereas macular DCP OCTA metrics provided independent, noninvasive prognostic information. Macular DCP OCTA parameters may serve as adjunctive biomarkers to refine DR risk stratification, particularly when UWF-FA is unavailable.
Authors
- Shinji Kakihara (ORCID: https://orcid.org/0000-0002-8433-8169)
- Anna Busza (ORCID: https://orcid.org/0009-0002-3677-5855)
- Ke Zhuang
- Amani A. Fawzi (ORCID: https://orcid.org/0000-0002-9568-3558)
- Elizabeth Pearce (ORCID: https://orcid.org/0000-0002-8010-228X)
- Taffeta C. Yamaguchi
Institutions
- Northwestern University (US)
- Boehringer Ingelheim (China) (CN)
- University College London (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1167/iovs.67.1.64
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00