ZM-306416 prevents ovariectomy-induced bone loss by promoting osteoblastogenesis and inhibiting osteoclastogenesis
Our study revealed that ZM has a dual anti-osteoporosis effect by promoting osteoblastogenesis and inhibiting osteoclastogenesis, which is mediated by activation of the Wnt/β-catenin signaling pathway and suppression of the NF-κB/MAPK cascades. These findings suggest that ZM could be a promising therapeutic agent for alleviating osteoporosis.
Authors
- Tianyu Chen (ORCID: https://orcid.org/0000-0001-7056-2947)
- Shuo Shi (ORCID: https://orcid.org/0000-0003-4387-3445)
- Dejian Yang
- Kedi Xu (ORCID: https://orcid.org/0000-0002-9059-3860)
- Jun Chang
- Wenquan Liang
- Yicheng Li
- Lianhui Zhao
- Junqi Chen
Institutions
- Anhui Medical University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Longgang Central Hospital (CN)
- Anhui Provincial Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Jinhua Central Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s13018-025-06654-7
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00