An Evidence-Based Assessment of Adjuvant Therapy in Autologous Fat Transfer

Deferoxamine emerged as the top translational candidate due to its dual role as an iron chelator and hypoxia-mimetic, reducing oxidative injury and promoting vascular regeneration. Our team is currently conducting ex vivo studies exposing human adipose grafts to deferoxamine and assessing viability with confocal microscopy. These results will inform optimal delivery and design of future clinical trials.

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Publication Details

Journal
Annals of Plastic Surgery
Published
2026-01-30
DOI
https://doi.org/10.1097/sap.0000000000004664
Primary Topic
Mesenchymal stem cell research
Type
article
Field-Weighted Citation Impact
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article

An Evidence-Based Assessment of Adjuvant Therapy in Autologous Fat Transfer

Claudy Sarpong, Antoun Bouz, In Young Oh, Subhas Gupta
Annals of Plastic Surgery
Mesenchymal stem cell research
article

An Evidence-Based Assessment of Adjuvant Therapy in Autologous Fat Transfer

Claudy Sarpong, Antoun Bouz, In Young Oh, Subhas Gupta
article en

Abstract

Deferoxamine emerged as the top translational candidate due to its dual role as an iron chelator and hypoxia-mimetic, reducing oxidative injury and promoting vascular regeneration. Our team is currently conducting ex vivo studies exposing human adipose grafts to deferoxamine and assessing viability with confocal microscopy. These results will inform optimal delivery and design of future clinical trials.

Annals of Plastic Surgery
Loma Linda University (US), Development Fund (NO)
Zero hunger
Openalex Percentile: Top 72%
Mesenchymal stem cell research
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