Identification and functional analysis of differential miRNAs in young and middle-aged adults with essential hypertension: exploring potential biomarkers and therapeutic targets

GPCPD1, regulated by hsa-miR-10b-5p, is a potential risk factor for EH, while CDKN1B, PDGFRA, and THBS2, regulated by upregulated miRNAs, may act as protective factors. These findings suggest new biomarkers and therapeutic targets for hypertension.

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Publication Details

Journal
Frontiers in Cardiovascular Medicine
Published
2026-01-30
DOI
https://doi.org/10.3389/fcvm.2025.1701938
Primary Topic
MicroRNA in disease regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Identification and functional analysis of differential miRNAs in young and middle-aged adults with essential hypertension: exploring potential biomarkers and therapeutic targets

Shaobo Chen, Fang Hao, Guo-Hong Yang, Xiu-Long Niu et al.
Frontiers in Cardiovascular Medicine
MicroRNA in disease regulation
article

Identification and functional analysis of differential miRNAs in young and middle-aged adults with essential hypertension: exploring potential biomarkers and therapeutic targets

Shaobo Chen, Fang Hao, Guo-Hong Yang, Xiu-Long Niu, Huixin Li, Wei Pang, Chao Liu, Qiong Guo, Xiao-Jing Wang, Wei Cai, Rui Shi, Tao Wang, Xin Zhang, Yu-Tian Liang
article en

Abstract

GPCPD1, regulated by hsa-miR-10b-5p, is a potential risk factor for EH, while CDKN1B, PDGFRA, and THBS2, regulated by upregulated miRNAs, may act as protective factors. These findings suggest new biomarkers and therapeutic targets for hypertension.

Frontiers in Cardiovascular MedicineVol. 12
Target (United States) (US), Shanghai Jiao Tong University (CN), International Paper (United States) (US), Alpha Medical (Slovakia) (SK), Tianjin Medical University (CN)
Good health and well-being
Openalex Percentile: Top 72%
MicroRNA in disease regulation
DOIOpen Access PDFOpenAlex
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Identification and functional analysis of differential miRNAs in young and middle-aged adults with essential hypertension: exploring potential biomarkers and therapeutic targets — Shaobo Chen, Fang Hao, et al. · Frontiers in Cardiovascular Medicine (2026) | TGRS Research Map | TGRS