Gout-Related Medication Use After Initiating Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies

For patients with gout and type 2 diabetes, SGLT2is may reduce gout-related medication use, which could, in turn, reduce exposure to the harmful cardiovascular-kidney-metabolic effects of NSAIDs and glucocorticoids in this high-risk population.

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Publication Details

Journal
Diabetes Care
Published
2026-01-30
DOI
https://doi.org/10.2337/dc25-1713
Primary Topic
Gout, Hyperuricemia, Uric Acid
Type
article
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article

Gout-Related Medication Use After Initiating Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies

Sharan Rai, Rozalina Grubina McCoy, Gregory J. Challener, Ran Abuhasira et al.
Diabetes Care
Gout, Hyperuricemia, Uric Acid
article

Gout-Related Medication Use After Initiating Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies

Sharan Rai, Rozalina Grubina McCoy, Gregory J. Challener, Ran Abuhasira, Nitzan Burrack, Na Lü, J. Antonio Aviña-Zubieta, Chio Yokose, Hyon K. Choi, Deborah J. Wexler
article en

Abstract

For patients with gout and type 2 diabetes, SGLT2is may reduce gout-related medication use, which could, in turn, reduce exposure to the harmful cardiovascular-kidney-metabolic effects of NSAIDs and glucocorticoids in this high-risk population.

Diabetes CareVol. 49(3)
University of Maryland, Baltimore (US), Harvard University (US), University of British Columbia (CA), Soroka Medical Center (IL), Foundation for the National Institutes of Health (US), Massachusetts General Hospital (US), Research Canada (CA), ENT and Allergy (US), Arthritis Research Centre of Canada (CA)
Good health and well-being
Openalex Percentile: Top 75%
Gout, Hyperuricemia, Uric Acid
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