RP-182 alleviated obstruction-induced renal fibrosis by reprogramming CD206+ macrophages
Our findings demonstrate that RP-182 alleviates obstructive renal fibrosis by specifically targeting CD206<sup>+</sup> macrophages, inhibiting their M2 polarization and MMT via β-catenin suppression. This work highlights RP-182 as a novel macrophage- directed therapeutic candidate for progressive kidney fibrosis.
Authors
- Ruyue Jin
- Zihan Wei (ORCID: https://orcid.org/0000-0002-4153-5314)
- Jiwen Cheng
- D Y Liu
- liwei WEI
- Dingjin Lu
- Jiawen Zhao (ORCID: https://orcid.org/0000-0001-9244-4837)
- Yunjie Yang
- Huixia Zhou
- Yutong Zhao
- Hualin Cao
- Xiaoye Chen
- Yuandong Tao
- Pin Li
- Guilong Chen
- Yuekang Chen
- Yangyang Wu
- Jianhua Wen
Institutions
- Sun Yat-sen University (CN)
- Ruijin Hospital (CN)
- Chinese PLA General Hospital (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Nanxi Mountain Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fphar.2026.1739457
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China