Osteoclasts affect the anti-cancer activity of NK cells
All together these data show that OCs negatively affect the NK cell cytotoxic activity, allowing the growth of NSCLC CSCs. Our findings reveal a previously unrecognized role of OCs in modulating the immune microenvironment by dampening NK cell function.
Authors
- Federico Mussano (ORCID: https://orcid.org/0000-0001-5800-0749)
- Giulia Bertolini (ORCID: https://orcid.org/0000-0002-8495-4594)
- Clarissa Orrico (ORCID: https://orcid.org/0000-0001-7781-3139)
- Riccardo Ferracini (ORCID: https://orcid.org/0000-0001-7654-0327)
- Ilaria Roato
- Matteo Visca
- Monica Parodi
Institutions
- Politecnico di Torino (IT)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Genoa (IT)
- Epigenomics (Germany) (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fimmu.2026.1730283
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione CRT
- Ministero della Salute
- Banca d'Italia
- Associazione Italiana per la Ricerca sul Cancro
- Fondazione Ricerca Molinette