Correlation of White Matter Lesions, Cerebral Blood Flow, and Cognitive Decline in Patients With Alzheimer’s Disease and Vascular Dementia

In a clinically mixed dementia cohort, the burden of WMLs and the magnitude of CBF reduction are strongly associated with the severity of cognitive impairment. These findings highlight the critical contribution of cerebrovascular pathology to cognitive dysfunction and underscore the value of quantitative imaging markers in understanding dementia's neurobiological substrates.