Molecular Docking of Cannabinoids: Achieving Binding Energies Exceeding –11 kcal/mol for His178 and Predicted Potency Over HU-210. Human Cannabinoid CB1 Receptor.

The amino acid residue His178 mediates high-efficacy agonism (as seen with HU-210) but exhibits limited accessibility. Docking analysis of the test structure revealed a unique interaction network involving His178, Met109, and the K376 within the deep binding pocket:

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-30
DOI
https://doi.org/10.5281/zenodo.18444784
Primary Topic
Cannabis and Cannabinoid Research
Type
article
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article

Molecular Docking of Cannabinoids: Achieving Binding Energies Exceeding –11 kcal/mol for His178 and Predicted Potency Over HU-210. Human Cannabinoid CB1 Receptor.

Yaroslav Zaitsev
Zenodo (CERN European Organization for Nuclear Research)
Cannabis and Cannabinoid Research
article

Molecular Docking of Cannabinoids: Achieving Binding Energies Exceeding –11 kcal/mol for His178 and Predicted Potency Over HU-210. Human Cannabinoid CB1 Receptor.

Yaroslav Zaitsev
article en

Abstract

The amino acid residue His178 mediates high-efficacy agonism (as seen with HU-210) but exhibits limited accessibility. Docking analysis of the test structure revealed a unique interaction network involving His178, Met109, and the K376 within the deep binding pocket:

Zenodo (CERN European Organization for Nuclear Research)
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Cannabis and Cannabinoid Research
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Molecular Docking of Cannabinoids: Achieving Binding Energies Exceeding –11 kcal/mol for His178 and Predicted Potency Over HU-210. Human Cannabinoid CB1 Receptor. — Yaroslav Zaitsev · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS