Oncogenic Role and Clinical Significance of NPM1 in Colorectal Cancer <i>via</i> the AKT/mTOR Signaling Pathway

NPM1 acts as an oncogenic driver in colorectal cancer by activating the AKT/mTOR signaling pathway. Elevated NPM1 expression highlights its potential as a diagnostic, prognostic, and therapeutic biomarker in CRC.

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Publication Details

Journal
Anticancer Research
Published
2026-01-30
DOI
https://doi.org/10.21873/anticanres.17982
Primary Topic
PI3K/AKT/mTOR signaling in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Oncogenic Role and Clinical Significance of NPM1 in Colorectal Cancer via the AKT/mTOR Signaling Pathway

Hong-Beum Kim, Sang-Gon Park, HEE-JEONG LEE
Anticancer Research
PI3K/AKT/mTOR signaling in cancer
article

Oncogenic Role and Clinical Significance of NPM1 in Colorectal Cancer via the AKT/mTOR Signaling Pathway

Hong-Beum Kim, Sang-Gon Park, HEE-JEONG LEE
article en

Abstract

NPM1 acts as an oncogenic driver in colorectal cancer by activating the AKT/mTOR signaling pathway. Elevated NPM1 expression highlights its potential as a diagnostic, prognostic, and therapeutic biomarker in CRC.

Anticancer ResearchVol. 46(2)
Chosun University (KR), Chosun University Hospital (KR)
Good health and well-being
Openalex Percentile: Top 72%
PI3K/AKT/mTOR signaling in cancer
DOISourceOpenAlex
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Oncogenic Role and Clinical Significance of NPM1 in Colorectal Cancer <i>via</i> the AKT/mTOR Signaling Pathway — Hong-Beum Kim, Sang-Gon Park, et al. · Anticancer Research (2026) | TGRS Research Map | TGRS