EMTscore infers divergent EMT pathways from omics data and enables rapid screening for correlated gene sets

Quantitative analyses of epithelial-mesenchymal transition (EMT) have been widely used in several areas of biomedical sciences due to its importance in development and cancer progression, but its multi-contextual nature requires standardization and implementation of gene set scoring methods beyond capacities of conventional tools. We developed EMTscore, a package that provides an efficient implementation of unbiased scoring methods for multiple EMT pathways using individual single-cell or bulk omics data, and the package allows rapid screening for relationships between EMT and other cellular processes.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-01-30
DOI
https://doi.org/10.64898/2026.01.27.702045
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00

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article

EMTscore infers divergent EMT pathways from omics data and enables rapid screening for correlated gene sets

Haimei Wen, Leonidas Bleris, Tian Hong
bioRxiv (Cold Spring Harbor Laboratory)
Single-cell and spatial transcriptomics
article

EMTscore infers divergent EMT pathways from omics data and enables rapid screening for correlated gene sets

Haimei Wen, Leonidas Bleris, Tian Hong
article en

Abstract

Quantitative analyses of epithelial-mesenchymal transition (EMT) have been widely used in several areas of biomedical sciences due to its importance in development and cancer progression, but its multi-contextual nature requires standardization and implementation of gene set scoring methods beyond capacities of conventional tools. We developed EMTscore, a package that provides an efficient implementation of unbiased scoring methods for multiple EMT pathways using individual single-cell or bulk omics data, and the package allows rapid screening for relationships between EMT and other cellular processes.

bioRxiv (Cold Spring Harbor Laboratory)
The University of Texas at Dallas (US)
National Science Foundation, National Institutes of Health
Partnerships for the goals
Openalex Percentile: Top 72%
Single-cell and spatial transcriptomics
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