Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study

In this study of FHS community-based original and offspring cohorts followed up over 7 decades, most TBIs occurred late in life and were related to falls. TBI was associated with an increased risk of long-term, all-cause mortality in a dose-dependent fashion, with dementia-related mortality largely contributing to this association. Preventing falls to reduce TBI could have important implications for dementia and mortality.

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Publication Details

Journal
JAMA Network Open
Published
2026-01-30
DOI
https://doi.org/10.1001/jamanetworkopen.2025.55138
Primary Topic
Traumatic Brain Injury Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study

Eukyung Yhang, Prajakta Joshi, Eden Price, Robert Burton et al.
JAMA Network Open
Traumatic Brain Injury Research
article

Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study

Eukyung Yhang, Prajakta Joshi, Eden Price, Robert Burton, Ashita S. Gurnani, R. Au, Sherral Devine, Shruti Durape, Michael L. Alosco, Jesse Mez, Yorghos Tripodis, Ting Fang Alvin Ang, Yulin Liu, Kurtis Chien-Young, Kristen Dams-O’Connor, Douglas I. Katz
article en

Abstract

In this study of FHS community-based original and offspring cohorts followed up over 7 decades, most TBIs occurred late in life and were related to falls. TBI was associated with an increased risk of long-term, all-cause mortality in a dose-dependent fashion, with dementia-related mortality largely contributing to this association. Preventing falls to reduce TBI could have important implications for dementia and mortality.

JAMA Network OpenVol. 9(1)
Boston University (US), City College of New York (US), Yale University (US), Framingham Heart Study (US), Icahn School of Medicine at Mount Sinai (US)
Good health and well-being
Openalex Percentile: Top 71%
Traumatic Brain Injury Research
DOIOpen Access PDFOpenAlex
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Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study — Eukyung Yhang, Prajakta Joshi, et al. · JAMA Network Open (2026) | TGRS Research Map | TGRS