Assessment of tissue homogenate levels of TGM1, PPL and KRT8 in a group of patients with HNSCC tumors and matched surgical margin samples

Our results suggest that impaired TGM1, PPL, and KRT8 signaling pathways might play a role in HNSCC, indicating their potential relevance for future diagnostic and therapeutic investigations. Further studies are needed to confirm our findings, clarify the mechanistic role of these proteins in disease progression, and assess their clinical utility.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-30
DOI
https://doi.org/10.3389/fonc.2026.1694449
Primary Topic
Protease and Inhibitor Mechanisms
Type
article
Field-Weighted Citation Impact
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article

Assessment of tissue homogenate levels of TGM1, PPL and KRT8 in a group of patients with HNSCC tumors and matched surgical margin samples

Mark Dawidek, Jakub Opyrchał, Radosław Lenckowski, Dariusz Nałęcz et al.
Frontiers in Oncology
Protease and Inhibitor Mechanisms
article

Assessment of tissue homogenate levels of TGM1, PPL and KRT8 in a group of patients with HNSCC tumors and matched surgical margin samples

Mark Dawidek, Jakub Opyrchał, Radosław Lenckowski, Dariusz Nałęcz, Zofia Złotopolska, Agata Świętek, Dorota Hudy, Joanna Katarzyna Strzelczyk
article en

Abstract

Our results suggest that impaired TGM1, PPL, and KRT8 signaling pathways might play a role in HNSCC, indicating their potential relevance for future diagnostic and therapeutic investigations. Further studies are needed to confirm our findings, clarify the mechanistic role of these proteins in disease progression, and assess their clinical utility.

Frontiers in OncologyVol. 16
Medical University of Silesia (PL), St Vincent Hospital (US), National Institute of Oncology (HU), Robotic Research (United States) (US), Institute of Molecular Pathology and Pathomorphology (RU), Robotic Technology (United States) (US), Hôpital Saint-Vincent-de-Paul (FR), University of Silesia in Katowice (PL), University of Rzeszów (PL)
Good health and well-being
Openalex Percentile: Top 73%
Protease and Inhibitor Mechanisms
DOIOpen Access PDFOpenAlex
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Assessment of tissue homogenate levels of TGM1, PPL and KRT8 in a group of patients with HNSCC tumors and matched surgical margin samples — Mark Dawidek, Jakub Opyrchał, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS