ROLE OF KOSHTA SHODHANOTTARA SANJIVINI VATI, PANCHANIMBA GHANVATI AND MEDHYACHATUSHKA GHRITA PRATIMARSHA NASYA IN THE MANAGEMENT OF STRESS INDUCED DIABETES

Hyperglycaemia refers to elevated blood glucose levels and is commonly linked to diabetes mellitus, a disorder of impaired carbohydrate metabolism caused by insulin deficiency or resistance. Stress acts as both causative and aggravating factor in diabetes. Diabetes is among the top global causes of death. Worldwide, 463 million people have type 2 diabetes, including 88 million in India, where prevalence is 11.3%. Of these, 45.6% are aware, 36.1% receive treatment, only 5.7% achieve glycaemic control, and nearly 25 million remain at risk. In Ayurveda, Madhumeha is described as Vatapradhana Tridoṣaja Vyadhi involving Ama, Meda, and Kleda Duṣṭi, based on Rakta Duṣṭi in Vidhishonitiya Adhyaya, corresponding to treatable hyperglycaemia. Objectives: to evaluate the combined efficacy of Sanjivini vati, Panchanimba ghanvati with kadaradi Kashaya anupana and Medhyachatushka ghrita pratimarsha nasya in the management of Madhumeha. To assess the efficacy of ongoing modern intervention in the management of hyperglycemia. And to compare the effects of both Groups. Methods: An open-labelled randomized controlled trial was conducted for 38 days on two groups. GroupA Sanjivini vati, panchanimba ghanvati with Kadaradi Kashaya anupana and Medhyachatushka ghrita pratimarsha nasya and GroupB ongoing modern intervention. Subjective and objective outcomes were assessed before and after treatment and analysed using contingency tables. Results: Group A Showed highly significant improvement in all subjective parameters (P < 0.0001) compared to Group B. Conclusion: The comprehensive treatment protocol showed highley significant improvement in both Objective and Subjective parameters. Multi model Ayurvedic interventions therefore offer enhanced therapeutic benefit in the management of Madhumeha.