Morphometric and Functional Evaluation of Nonrenal Vasculature in Female and Male PKD/Mhm (Cy/+) Rats
Six-month-old male rats with PKD, but not females, display endothelial dysfunction, impaired smooth muscle contraction/relaxation, pathological changes in aortic morphometry, and increased apoptosis, providing a model for studying vascular complications in ADPKD.
Authors
- Patricia Kraft
- Sevil Korkmaz‐Icöz (ORCID: https://orcid.org/0000-0003-3613-5807)
- Baoer Liu
- Maik Brune
- Matthias Karck
- Gábor Szabó
- Alex Ali Sayour
- Tilmann Stephan Clanget
- Tobias Mayer
- Franz Schaefer
- Ming Ma
- Kim Bierhoff
Institutions
- Semmelweis University (HU)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Hospital in Halle (DE)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1159/000550553
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Heidelberger Stiftung Chirurgie