High resolution genome-wide SNP array analyses on matched colorectal-based lung and brain metastases
Brain metastases of CRC showed more cn-LOH regions than lung metastases. Potentially affected genes within these regions could influence signaling pathways (e.g., PI3K/AKT signaling) as well as transcriptional processes. Perspectively, increased awareness of specific genetic characteristics can potentially increase the chance of early diagnosis of brain metastases, which could contribute to improved treatment options.
Authors
- Lydia Holland
- Hendrik Bläker (ORCID: https://orcid.org/0000-0002-2497-8172)
- Vivian-Pascal Brandt
- Ronald Koschny (ORCID: https://orcid.org/0000-0003-2117-9137)
- Heidrun Holland (ORCID: https://orcid.org/0000-0002-3677-592X)
- Wolf Müller
- Erdem Güresir
- Ulf Nestler
- Carolin Sander
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Hospital Leipzig (DE)
- Saxon Institute for Applied Biotechnology (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1007/s00432-026-06427-7
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universität Leipzig