Surgical treatment of myxopapillary ependymoma: an institutional case series of 56 patients

MPEs are benign tumors that arise predominantly from the filum terminale. Resection can be curative, especially for well-marginated tumors arising from the proximal filum terminale. Despite their benign nature, the tumors' lack of a capsule, friable tumor consistency, and frequent direct contact with the CSF and cauda equina create a propensity for local recurrence and CSF dissemination, especially for larger and distally originating tumors. Thus, long-term follow-up is recommended for all patients as is early surgical intervention for small, incidental MPEs.

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Publication Details

Journal
Journal of Neurosurgery Spine
Published
2026-01-30
DOI
https://doi.org/10.3171/2025.9.spine25650
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Surgical treatment of myxopapillary ependymoma: an institutional case series of 56 patients

Christopher E. Mandigo, Justin A. Neira, Jane Kostadinov, Phoebe Greenwald et al.
Journal of Neurosurgery Spine
Glioma Diagnosis and Treatment
article

Surgical treatment of myxopapillary ependymoma: an institutional case series of 56 patients

Christopher E. Mandigo, Justin A. Neira, Jane Kostadinov, Phoebe Greenwald, Peter D. Angevine, Alexander G. Khandji, Evan F Joiner, Andrew K Chan, Paul C McCormick
article en

Abstract

MPEs are benign tumors that arise predominantly from the filum terminale. Resection can be curative, especially for well-marginated tumors arising from the proximal filum terminale. Despite their benign nature, the tumors' lack of a capsule, friable tumor consistency, and frequent direct contact with the CSF and cauda equina create a propensity for local recurrence and CSF dissemination, especially for larger and distally originating tumors. Thus, long-term follow-up is recommended for all patients as is early surgical intervention for small, incidental MPEs.

Journal of Neurosurgery Spine
Seattle Children's Hospital (US), University of Washington (US), New York Hospital Queens (US), Presbyterian Hospital (US)
Good health and well-being
Openalex Percentile: Top 72%
Glioma Diagnosis and Treatment
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