Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells
This study provides the first comprehensive lactylome profile of Pg-infected HUVECs, identifying lysine lactylation as a novel mechanism linking periodontal infection to endothelial dysfunction. These findings offer a new molecular framework for understanding the pathogenesis of periodontitis-associated cardiovascular diseases and suggest potential biomarkers and therapeutic targets.
Authors
- Xiao‐Hui Zheng (ORCID: https://orcid.org/0000-0002-5128-6649)
- Z Li
- Xuedong Zhou (ORCID: https://orcid.org/0000-0002-9319-7302)
- Qinrui Wu
- Tao Gong (ORCID: https://orcid.org/0000-0001-7869-3968)
- Xian Peng
Institutions
- Sichuan University (CN)
- National Clinical Research (US)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fcimb.2026.1706727
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China