The association of osteoarthritis with the risk of de novo inflammatory arthritis in patients receiving immune checkpoint inhibitors: a retrospective study

OA was more prevalent among ICI-treated patients developing IA-irAE than those who did not. Hand OA was the most common OA pattern in IA-irAE patients. Preexisting OA, melanoma and a family history of AID were risk factors for IA-irAE.

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Publication Details

Journal
medRxiv
Published
2026-01-30
DOI
https://doi.org/10.64898/2026.01.28.26344880
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00

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article

The association of osteoarthritis with the risk of de novo inflammatory arthritis in patients receiving immune checkpoint inhibitors: a retrospective study

S. Chen, Uma Thanarajasingam, Hu Zeng, Xingxing Zhu et al.
medRxiv
Cancer Immunotherapy and Biomarkers
article

The association of osteoarthritis with the risk of de novo inflammatory arthritis in patients receiving immune checkpoint inhibitors: a retrospective study

S. Chen, Uma Thanarajasingam, Hu Zeng, Xingxing Zhu, Cynthia S Crowson
article en

Abstract

OA was more prevalent among ICI-treated patients developing IA-irAE than those who did not. Hand OA was the most common OA pattern in IA-irAE patients. Preexisting OA, melanoma and a family history of AID were risk factors for IA-irAE.

medRxiv
Mayo Clinic (US), WinnMed (US), First Affiliated Hospital of Xiamen University (CN), Mayo Clinic in Florida (US)
Mayo Foundation for Medical Education and Research, National Institutes of Health
Good health and well-being
Openalex Percentile: Top 73%
Cancer Immunotherapy and Biomarkers
DOIOpen Access PDFOpenAlex
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The association of osteoarthritis with the risk of de novo inflammatory arthritis in patients receiving immune checkpoint inhibitors: a retrospective study — S. Chen, Uma Thanarajasingam, et al. · medRxiv (2026) | TGRS Research Map | TGRS