Esophageal functional phenotypes in refractory GERD-related chronic cough

<title>Extract</title> Gastroesophageal reflux disease (GERD) has been increasingly recognized as a cause of chronic cough (CC) in Japan [1]. While proton pump inhibitors (PPIs) are commonly prescribed to diagnose and treat GERD-associated chronic cough (GERC), some patients exhibit refractory responses to some specific treatments [1]. Emerging evidence indicates that the pathogenesis of refractory-GERC (R-GERC) is significantly affected by non-acid reflux, esophageal mucosal injury, and esophageal dysmotility [2, 3]. However, the relationship between esophageal functional characteristics and cough-related outcomes in patients with R-GERC remains poorly comprehended.