KLF4 orchestrates a Ccl2+ fibroblast-mediated inflammatory network driving preterm birth
This study reveals that the fibroblast subpopulation Ccl2+fib contributes to preterm birth through a KLF4-dependent inflammatory regulatory network. KLF4 downregulation significantly reduces infection-induced preterm birth rates and adverse pregnancy outcomes, suggesting that KLF4 is a critical therapeutic target for preterm birth.
Authors
- Lulu Sun (ORCID: https://orcid.org/0000-0001-8876-5099)
- Xin Hong (ORCID: https://orcid.org/0000-0002-9671-0116)
- Jing Gao (ORCID: https://orcid.org/0000-0002-9445-4892)
- Yaqing Chang
- Yuan Su
- Fang Wang
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- First Hospital of Shijiazhuang (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fmed.2025.1700275
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00