<i>APOE4</i> and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology
In patients with ICAS, cognitive impairment was more prevalent in carriers than in non-carriers. Carriers showed greater stenosis burden and lower plasma Aβ42/40 ratios. After full adjustment (stroke, CSVD, and AD biomarkers), APOE ε4 remained associated with cognitive impairment. Female carriers had substantially higher odds of cognitive impairment.
Authors
- Caiyan Liu (ORCID: https://orcid.org/0009-0004-9352-6155)
- Yinxi Zou (ORCID: https://orcid.org/0000-0001-7150-4167)
- Qiuyu Yu (ORCID: https://orcid.org/0000-0002-5452-2918)
- Zijue Wang
- Linwen Liu
- Huanyu Zhou (ORCID: https://orcid.org/0000-0001-9844-132X)
- Shiwen Wu
- Weihai Xu (ORCID: https://orcid.org/0000-0003-1057-0579)
- Haoyao Guo
- Yiyang Liu
- Hebo Wang
- Qianqian Si
- Mingli Li
- Zhibing Ai
- Anqi Cheng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Chinese PLA General Hospital (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- People's Liberation Army No. 150 Hospital (CN)
- Hebei General Hospital (CN)
- Taihe Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1002/alz.71087
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 33.12
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital
- Peking Union Medical College
- National Science and Technology Major Project
- National Science Fund for Distinguished Young Scholars