Impact of sex, age and body composition on rilpivirine and cabotegravir trough concentrations in people with HIV receiving long-acting injectable antiretroviral therapy
Sex, age and muscle mass significantly influence cabotegravir-but not rilpivirine-trough concentrations in PWH receiving LAI therapy. Therapeutic drug monitoring combined with body composition assessment may help to optimize dosing interval adjustment.
Authors
- Maddalena Matone
- Anna Lisa Ridolfo (ORCID: https://orcid.org/0000-0003-1106-6219)
- Cristina Gervasoni (ORCID: https://orcid.org/0000-0002-4922-6495)
- Andrea Rabbione
- Sara Soloperto (ORCID: https://orcid.org/0000-0003-2303-6463)
- A D’Avolio
- Dario Cattaneo
- Davide Moschese
- A. Giacomelli
- Chiara Fusetti
- Andrea Gori
- Maria Vittoria Cossu
Institutions
- Humanitas University (IT)
- University of Milan (IT)
- ASST Fatebenefratelli Sacco (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Turin (IT)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1093/jac/dkag024
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00