Loss of Cathepsin K Impairs Collagen Biogenesis and Enhances Actin Polymerization in Trabecular Meshwork
Our findings underscore the multifaceted role of CTSK in maintaining critical cellular processes within the TM. Specifically, we have shown that CTSK is closely involved in regulating ECM homeostasis, influencing calcium signaling, and governing cytoskeletal dynamics and TM cellularity.
Authors
- Emma H. Doud (ORCID: https://orcid.org/0000-0003-0049-0073)
- Padmanabhan P. Pattabiraman (ORCID: https://orcid.org/0000-0003-1902-0493)
- Avinash Soundararajan (ORCID: https://orcid.org/0000-0001-9557-0038)
- Michelle Surma
- Rodahina Philihina Pasteurin
- Krishna Jayasankar
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1167/iovs.67.1.63
- Citations
- 1
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 24.82
Funders
- Research to Prevent Blindness
- Glaucoma Foundation
- Indiana University-Purdue University Indianapolis
- National Institutes of Health
- School of Medicine, Indiana University