Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Recreational smoking-administered ketamine use appears to be associated with dose-dependent psychiatric symptoms, load-dependent working memory impairment, selective hippocampal subregion volumetric differences and altered network connectivity aligned with N-methyl-D-aspartate- (NMDA) receptor distribution.

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Publication Details

Journal
Addiction
Published
2026-01-29
DOI
https://doi.org/10.1111/add.70331
Primary Topic
Treatment of Major Depression
Type
article
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article

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Chang Li, Chu‐Chung Huang, Chia-Chun Hung, Ching‐Po Lin et al.
Addiction
Treatment of Major Depression
article

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Chang Li, Chu‐Chung Huang, Chia-Chun Hung, Ching‐Po Lin, Kun‐Hsien Chou, Yi‐Hsuan Liu, Pei‐lin Lee, Marc N. Potenza, Tony Szu‐Hsien Lee
article en

Abstract

Recreational smoking-administered ketamine use appears to be associated with dose-dependent psychiatric symptoms, load-dependent working memory impairment, selective hippocampal subregion volumetric differences and altered network connectivity aligned with N-methyl-D-aspartate- (NMDA) receptor distribution.

Addiction
National Taiwan Normal University (TW), National Yang Ming Chiao Tung University (TW), National Health Research Institutes (TW), Yale University (US), Taipei City Hospital (TW), Ministry of Health and Welfare (TW), Connecticut Mental Health Center (US), Connecticut Department of Labor (US), East China Normal University (CN), Columbia University (US)
Good health and well-being
Openalex Percentile: Top 72%
Treatment of Major Depression
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