Uranyl-Enabled Photocatalytic C(sp <sup>3</sup> )–H Functionalization with Azoles
Under mild conditions, uranyl nitrate catalyzed C(sp<sup>3</sup>)-center/azole coupling without external additives, offering a broad substrate scope and high yields (up to 95%). The method was further validated under sunlight and in scale-up experiments, highlighting its industrial potential. Experimental and theoretical studies show that uranyl nitrate acts via both hydrogen-atom transfer (HAT) and non-HAT concerted proton-electron transfer mechanisms. This approach provides a green, efficient protocol for C(sp<sup>3</sup>)-azole bond formation.
Authors
- Y Z Luo (ORCID: https://orcid.org/0009-0009-6783-8733)
- Yan-Xin Jiang
- Jing Su (ORCID: https://orcid.org/0000-0002-6895-2150)
- Songbai Tang
- Shu-Yun Zhang
- Jia-Hao Ruan
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1021/acs.orglett.5c05026
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00