Treatment Efficacy, Chemoradiotherapy Benefits, and Survival Disparities by Histology in Primary Mediastinal Germ Cell Tumors: 15‐Year Results of a Single‐Center Cohort Study
The BEP regimen, which was effective in testicular GCTs, demonstrates activity in PMGCTs. Seminomas showed superior therapeutic effect and survival compared to non-seminomas. For non-seminomas, the first-line response might predict PFS, and mediastinal radiotherapy might provide additional survival benefits. These findings highlight histology-driven prognostic stratification for PMGCTs and multimodal management for primary mediastinal non-seminoma GCTs.
Authors
- Guangming Tian
- Hanxiao Chen (ORCID: https://orcid.org/0000-0001-8240-7047)
- Jian Fang (ORCID: https://orcid.org/0000-0002-1077-3686)
- Lu Wang (ORCID: https://orcid.org/0000-0003-2617-655X)
- Xiangjuan Ma
- Jun Nie
- Sen Han
- Ling Dai (ORCID: https://orcid.org/0009-0005-5386-9089)
- Weiheng Hu (ORCID: https://orcid.org/0000-0001-5126-4020)
- Xiaoling Chen
- Jieran Long
- Panpan Zhang
- Ziran Zhang
- Jindi Han
- Jie Zhang
- Di Wu
Institutions
- Ministry of Education (ET)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Asia-Pacific Journal of Clinical Oncology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1111/ajco.70073
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00