From Ostrich to Mouse to Human: Translation of the Functional Liver PET Tracer [<sup>68</sup>Ga]Ga-TEoS-DAZA.
Ga]Ga-TEoS-DAZA was shown to be a suitable hepatobiliary tracer using both mice and ostrich embryos as preclinical models; however, there were limits in translatability in both models because of a distinctly faster hepatic uptake and biliary excretion (mice) or a slower biliary excretion (ostrich embryo) compared with that in the human.
Authors
- Steffen Wiegand
- Tobias L. Ross
- Robert Drescher (ORCID: https://orcid.org/0000-0003-1890-3294)
- Mari Teuter
- Julia Greiser (ORCID: https://orcid.org/0000-0002-3779-6298)
- Silav Al-Bazaz
- Olga Perkas (ORCID: https://orcid.org/0009-0002-1496-740X)
- Frank M. Bengel (ORCID: https://orcid.org/0000-0003-4529-7963)
- Michael Bauer (ORCID: https://orcid.org/0000-0002-2666-859X)
- Jens P. Bankstahl (ORCID: https://orcid.org/0000-0003-4735-4490)
- Adrian Tibor Press (ORCID: https://orcid.org/0000-0002-6089-6764)
- Thomas Winkens (ORCID: https://orcid.org/0000-0002-8958-4801)
- Marta Pomraenke
- Christian Kuehnel
- Mitali Sonawane
- Julia Greiser
- Martin Freesmeyer
Institutions
- Medizinische Hochschule Hannover (DE)
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- PubMed
- Published
- 2026-04-01
- DOI
- https://doi.org/10.2967/jnumed.125.271020
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00