A peptide nucleic acid-based pretargeting approach using 161Tb for radionuclide therapy in a murine tumor model
Compared to conventional non-pretargeted radionuclide therapy, PNA-based pretargeted <sup>161</sup>Tb radionuclide therapy reduced systemic radiation exposure, significantly decreased hematotoxicity, and suppressed tumor growth in tumor-bearing mice.
Authors
- Yuyue Feng
- Zi Wang (ORCID: https://orcid.org/0000-0002-3953-0493)
- Wenli Li (ORCID: https://orcid.org/0000-0003-1598-3217)
- Xia Zhu
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Hua Pang
- Lili Guan
- Wenbo Li
- Jia Li
- Xin Xiang
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s13550-026-01382-3
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00