Hepatocyte growth factor as a driver of synovial inflammation and therapeutic resistance in rheumatoid arthritis
HGF primarily acts on synovial fibroblasts, driving an IL-6-mediated inflammatory amplification loop that may contribute to therapeutic resistance in RA. Targeting the HGF-c-Met pathway could represent a novel strategy for overcoming treatment refractoriness in RA.
Authors
- Keiichiro Kadoba (ORCID: https://orcid.org/0000-0002-8242-9374)
- Masao Katsushima (ORCID: https://orcid.org/0009-0007-0033-1757)
- Lê Thị Thanh Thủy (ORCID: https://orcid.org/0000-0003-4460-735X)
- Masao Tanaka
- Motomu Hashimoto (ORCID: https://orcid.org/0000-0002-9241-060X)
- K. Mamoto (ORCID: https://orcid.org/0000-0002-7541-3745)
- K. Murata
- Sang Quang Tran Nguyen
- Ryuhei Ishihara
- Trần Trung Dũng
- Ryu Watanabe
- Takeshi Iwasaki (ORCID: https://orcid.org/0000-0002-9326-3699)
- Yutaro Yamada
- Thanh Duc Tran
- Tadashi Okano
- Khanh Van Nguyen
- Quang Minh Dang
- Hongxin Sun
- Hui Zhang
- Hiromu Ito
Institutions
- Sun Yat-sen University (CN)
- Kyoto University (JP)
- Kurashiki Central Hospital (JP)
- Metropolitan University (RS)
- Vinmec Times City International Hospital (VN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- VinUniversity (VN)
- Universidad Metropolitana (VE)
- Osaka Metropolitan University (JP)
- Tokyo Metropolitan University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fimmu.2026.1718591
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science