Novel approaches in linkage of data sources to explore the associations between purchase of opioid prescriptions during pregnancy and adverse neonatal outcomes
Linking APCD and PDMP enabled a comprehensive assessment of prescribed opioid exposure. Opioid purchases were associated with increased risk of NOWS and modestly higher odds of PT birth. The dose and timing of opioid purchase were key determinants of NOWS. Payment source was not associated with differences in neonatal risk.
Authors
- Nahed O. ElHassan (ORCID: https://orcid.org/0000-0003-0868-8420)
- C Akmyradov
- Ruchira Mahashabde (ORCID: https://orcid.org/0000-0003-2448-1489)
- Robert E. McGehee
- Teresa J. Hudson (ORCID: https://orcid.org/0000-0002-6672-6774)
- Corey J. Hayes (ORCID: https://orcid.org/0000-0002-7776-6157)
- Xiaotong Han
- Bradley C. Martin
- Chenghui Li
Institutions
- Arkansas Children's Hospital (US)
- University of Arkansas Medical Center (US)
- Arkansas Department of Health (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1371/journal.pone.0340816
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Center for Advancing Translational Sciences