Relationship between age and severity of cognitive impairment at diagnosis for early‐onset and late‐onset Alzheimer's disease: Comparison of LEADS and ADNI
Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) participants each displayed cognitive impairments relative to same-aged peers across most domains. Both groups displayed positive relationships between impairment among non-amnestic cognitive domains and baseline age. This relationship displayed a significantly greater effect in EOAD than LOAD, with domains of Processing Speed/Attention and Executive Functioning skills being the most pronounced. Of those participants developing AD, age displayed a disproportionate impact on their symptom onset.
Authors
- D. Jones
- Marı́a C. Carrillo
- Kala Kirby
- Kyle Womack
- Thomas S. Wingo
- Emily Rogalski
- Paul Aisen
- Steven Salloway
- Bradford C. Dickerson
- Liana G. Apostolova
- Lawrence S. Honig
- Ranjan Duara
- Gregory S. Day
- Dustin B. Hammers
- Erik Musiek
- Alexandra Touroutoglou
- Gil D. Rabinovici
- Sujuan Gao
- David Clark
- Laurel Beckett
- Ian Grant
- Raymond Scott Turner
- Rema Reman
- Mario F. Mendez
- Alexander Taurone
- Ani Eloyan
- for the Alzheimer's Disease Neuroimaging Initiative
- Erik C. B. Johnson
- Prashanthi Vemuri
- Neill R. Graff‐Radford
- Sharon J. Sha
- Alireza Atri
- Jeffrey L. Dage
- Kelly Nudelman
- Meghan Riddle
- David A. Wolk
- Chiadi U. Onyike
- Maryanne Thangarajah
- Joseph C. Masdeu
- Renaud La Joie
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Alzheimer's Association (US)
- Autism Research Institute (US)
- Houston Methodist (US)
- Mayo Clinic (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Georgetown University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- University of California System (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Mount Sinai Medical Center (US)
- Methodist Hospital (US)
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Florida (US)
- Weill Cornell Medicine (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1002/alz.71160
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association