Patient-reported outcomes among patients with mantle cell lymphoma or chronic lymphocytic leukemia receiving pirtobrutinib in the BRUIN phase 1/2 study: final analysis
The final analysis from the BRUIN trial demonstrates stability in PROs throughout the duration of treatment with pirtobrutinib. Most patients with CLL/SLL and MCL reported stable or improved outcomes throughout the study.
Authors
- Ian W. Flinn (ORCID: https://orcid.org/0000-0001-6724-290X)
- Constantine S. Tam
- Nicole Lamanna (ORCID: https://orcid.org/0000-0003-3331-9491)
- C Cheah
- Lisa M. Hess (ORCID: https://orcid.org/0000-0003-3631-3941)
- Koji Izutsu (ORCID: https://orcid.org/0000-0001-9129-8057)
- Angély Loubert (ORCID: https://orcid.org/0000-0002-7588-431X)
- Naleen Raj Bhandari (ORCID: https://orcid.org/0000-0002-4452-8021)
- Lindsey E. Roeker (ORCID: https://orcid.org/0000-0002-3806-059X)
- K. Patel
- Joanna Meehan Rhodes (ORCID: https://orcid.org/0000-0002-5068-9040)
- T Eyre
- Paolo Ghia
- Shuo Ma
- Catherine C. Coombs
- John F. Seymour
- Jennifer R. Brown
- Nirav N. Shah
- Wojciech Jurczak
- Paolo B. Abada
- William G. Wierda
- Jennifer A. Woyach
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Vita-Salute San Raffaele University (IT)
- Eli Lilly (United States) (US)
- Sarah Cannon Research Institute (GB)
- University of California, Irvine (US)
- Medical College of Wisconsin (US)
- Peter MacCallum Cancer Centre (AU)
- Churchill Hospital (GB)
- Cancer Institute (WIA) (IN)
- Sir Charles Gairdner Hospital (AU)
- National Cancer Center (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Sarah Cannon (US)
- Dana-Farber Cancer Institute (US)
- National Institute of Oncology (HU)
- IRCCS Ospedale San Raffaele (IT)
- Tennessee Oncology (US)
- Scripps MD Anderson Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- The Ohio State University (US)
- Monash University (AU)
- Columbia University (US)
Publication Details
- Journal
- Current Medical Research and Opinion
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1080/03007995.2025.2607542
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00