Identification of a pathological feed‐forward loop linking succinate, HIF1α signalling and vascular remodelling in abdominal aortic aneurysm
Our study proposes succinate as a driver of AAA through a feed-forward loop involving HIF1α signalling and VSMC phenotypic switching. Our work identifies the succinate-HIF1α axis as a promising therapeutic target to disrupt key pathological processes underlying AAA.
Authors
- Silke Griepke
- Janne Fuglsang Hansen (ORCID: https://orcid.org/0009-0001-6610-1643)
- J. S. Lindholt
- L. M. Rasmussen
- P. S. Jensen
- K. L. Kristensen
- G. L. Tripodi
- D. F. J. Ketelhuth
Institutions
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1111/eci.70170
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Novo Nordisk
- Syddansk Universitet
- Novo Nordisk Fonden
- HORIZON EUROPE Framework Programme